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1

Synthesis, conformational analysis, and antiarrhythmic properties of 7-benzyl-3-thia-7-azabicyclo[3.3.1]nonan-9-one, 7-benzyl-3-thia-7-azabicyclo[3.3.1]nonane hydroperchlorate, and 7-benzyl-9-phenyl-3-thia-7-azabicyclo[3.3.1]nonan-9-ol hydroperchlorate and derivatives. Single-crystal x-ray diffraction analysis and evidence for chair-chair and chair-boat conformers in the solid state

Bailey, Bruce R., Berlin, K. Darrell, Holt, Elizabeth M., Scherlag, Benjamin J., Lazzara, Ralph, Brachmann, Johannes, Van der Helm, Dick, Powell, Douglas R., Pantaleo, Nantelle S., Ruenitz, Peter C.

Journal:

Journal of Medicinal Chemistry

Year:

1984

Language:

english

File:

PDF, 1.27 MB

english, 1984

2

Phenolic metabolites of clomiphene. [(E,Z)-2-[4-(1,2-diphenyl-2-chlorovinyl)phenoxy]ethyl]diethylamine. Preparation, electrophilicity, and effects in MCF 7 breast cancer cells

Ruenitz, Peter C., Arrendale, Richard F., Schmidt, Walter F., Thompson, Carolyn B., Nanavati, Nitin T.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 857 KB

english, 1989

3

Analogs of sparteine. IV. Mass spectral features of a series of N, N′-disubstituted bispidines

Peter C. Ruenitz, Edward E. Smissman, Deborah S. Wright

Journal:

Journal of Heterocyclic Chemistry

Year:

1977

File:

PDF, 182 KB

1977

4

Mechanisms of growth inhibition by nonsteroidal antioestrogens in human breast cancer cells

Robert L. Sutherland, Colin K.W. Watts, Rosemary E. Hall, Peter C. Ruenitz

Journal:

Journal of Steroid Biochemistry

Year:

1987

Language:

english

File:

PDF, 822 KB

english, 1987

5

Primary deuterium isotope effect in the oxidation of an iminium ion by aldehyde oxidase

Peter C. Ruenitz, H.Greg Thomas

Journal:

Archives of Biochemistry and Biophysics

Year:

1985

Language:

english

File:

PDF, 264 KB

english, 1985

6

7-Aza analogs of the analgetic agent azabicyclane. Synthesis and pharmacologic analysis

Smissman, Edward E., Ruenitz, Peter C.

Journal:

Journal of Medicinal Chemistry

Year:

1976

Language:

english

File:

PDF, 418 KB

english, 1976

7

Mechanistic aspects of oxidation of N-substituted 5H-dibenz[c,e]azepines by aldehyde oxidase

H. Greg Thomas, Peter C. Ruenitz

Journal:

Journal of Heterocyclic Chemistry

Year:

1984

File:

PDF, 500 KB

1984

8

Inhibition of rabbit liver microsomal oxidative metabolism and substrate binding by tamoxifen and the geometric isomers of clomiphene

Peter C. Ruenitz, Mo M. Toledo

Journal:

Biochemical Pharmacology

Year:

1980

Language:

english

File:

PDF, 480 KB

english, 1980

9

Carboxylic Acid Analogues of Tamoxifen: ( Z )-2-[ p -(1,2-Diphenyl-1-butenyl)phenoxy]- N,N -dimethylethylamine. Estrogen Receptor Affinity and Estrogen Antagonist Effects in MCF-7 Cells

Kraft, Kelly S., Ruenitz, Peter C., Bartlett, Michael G.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 159 KB

english, 1999

10

Antiestrogens. 3. Estrogen receptor affinities and antiproliferative effects in MCF-7 cells of phenolic analogs of trioxifene, [3,4-dihydro-2-(4-methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl[methanone

Jones, Charles D., Blaszczak, Larry C., Goettel, Mary E., Suarez, Tulio, Crowell, Thomas A., Mabry, Thomas E., Ruenitz, Peter C., Srivatsan, V.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.09 MB

english, 1992

11

Analogs of sparteine. 5. Antiarrhythmic activity of selected N,N'-disubstituted bispidines

Ruenitz, Peter C., Mokler, Corwin M.

Journal:

Journal of Medicinal Chemistry

Year:

1977

Language:

english

File:

PDF, 566 KB

english, 1977

12

Identification of new triarylethylene oxyalkanoic acid analogues as bone selective estrogen mimetics

Valeria N Rubin, Peter C Ruenitz, F.Douglas Boudinot, Jason L Boyd

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 189 KB

english, 2001

13

Definition of two distinct mechanisms of action of antiestrogens on human breast cancer cell proliferation using hydroxytriphenylethylenes with high affinity for the estrogen receptor

Robert L. Sutherland, Colin K.W. Watts, Peter C. Ruenitz

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 433 KB

english, 1986

14

Chemical and biochemical characteristics of O-demethylation of chlorotrianisene in the rat

Peter C. Ruenitz, Mo M. Toledo

Journal:

Biochemical Pharmacology

Year:

1981

Language:

english

File:

PDF, 502 KB

english, 1981

15

Analogs of sparteine. I. Reexamination of the reaction of N-methyl-4-piperidone with formaldehyde and methylamine. Revised synthesis of N,N'-dimethylbispidinone

Smissman, Edward E., Ruenitz, Peter C., Weis, James A.

Journal:

Journal of Organic Chemistry

Year:

1975

Language:

english

File:

PDF, 293 KB

english, 1975

16

Estrogen receptor binding and estrogenic/antiestrogenic effects of two new metabolites of nitromiphene, 2-[p-[2-nitro-1-(4-methoxyphenyl)-2-phenylvinyl]phenoxy]-N-ethylpyrrolidine

Ruenitz, Peter C., Bagley, Jerome R., Mokler, Corwin M.

Journal:

Journal of Medicinal Chemistry

Year:

1983

Language:

english

File:

PDF, 746 KB

english, 1983

17

Estrogenic Triarylethylene Acetic Acids: Effect of Structural Variation on Estrogen Receptor Affinity and Estrogenic Potency and Efficacy in MCF-7 Cells

Ruenitz, Peter C., Bourne, Caryl S., Sullivan, Kelly J., Moore, Susan A.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 222 KB

english, 1996

18

Metabolism of clomiphene in the rat: Estrogen receptor affinity and antiestrogenic activity of clomiphene metabolites

Peter C. Ruenitz, Jerome R. Bagley, Corwin M. Mokler

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 876 KB

english, 1983

19

Antiarrhythmic activity of some N-alkylbispidinebenzamides

Ruenitz, Peter C., Mokler, Corwin M.

Journal:

Journal of Medicinal Chemistry

Year:

1979

Language:

english

File:

PDF, 401 KB

english, 1979

20

Resolution, absolute configuration, and antiarrhythmic properties of the enantiomers of disopyramide, 4-(diisopropylamino)-2-(2-pyridyl)-2-phenylbutyramide

Burke, Terrence R., Nelson, Wendel L., Mangion, Margaret, Hite, Gilbert J., Mokler, Corwin M., Ruenitz, Peter C.

Journal:

Journal of Medicinal Chemistry

Year:

1980

Language:

english

File:

PDF, 668 KB

english, 1980

21

Estrogen receptor affinity and effects on MCF-7 cell growth of triarylethylene carboxylic acids related to tamoxifen

Wilson, Susanne, Ruenitz, Peter C., Ruzicka, Jan A.

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1992

Language:

english

File:

PDF, 325 KB

english, 1992

22

Characterization of mcf 7 breast cancer cell growth inhibition by the antiestrogen nitromifene (CI 628) and selected metabolites

Peter C. Ruenitz, Carolyn B. Thompson, V. Srivatsan

Journal:

Journal of Steroid Biochemistry

Year:

1989

Language:

english

File:

PDF, 537 KB

english, 1989

23

Analogues of sparteine. II. Synthesis of N-monoalkylbispidines and N,N'-dialkylbispidines

Smissman, Edward E., Ruenitz, Peter C.

Journal:

Journal of Organic Chemistry

Year:

1976

Language:

english

File:

PDF, 684 KB

english, 1976

24

Estrogenic tamoxifen derivatives: Categorization of intrinsic estrogenicity in MCF-7 cells

Peter C. Ruenitz, Susan A. Moore, Kelly S. Kraft, Caryl S. Bourne

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1997

Language:

english

File:

PDF, 556 KB

english, 1997

25

Estrogenic and antiestrogenic activity of monophenolic analogs of tamoxifen, [(Z)-2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine]

Ruenitz, Peter C., Bagley, Jerome R., Mokler, Corwin M.

Journal:

Journal of Medicinal Chemistry

Year:

1982

Language:

english

File:

PDF, 658 KB

english, 1982

26

Affinity of ligands other than triarylethylenes for liver microsomal antiestrogen binding sites

Peter C. Ruenitz, Jerome R. Bagley

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 286 KB

english, 1985

27

Reduction of iminium ethers with sodium boro[3H] hydride. Preparation of tritium labelled clomiphene and nitromiphene (CI 628)

Peter C. Ruenitz, Jerome R. Bagley

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1984

Language:

english

File:

PDF, 248 KB

english, 1984

28

Formation of benzophenone and α,α-diarylacetophenone metabolites of the antiestrogen nitromiphene (CI628) in the presence of rat cecal contents

Peter C. Ruenitz, Jerome R. Bagley

Journal:

Year:

1983

Language:

english

File:

PDF, 267 KB

english, 1983

29

Use of the mannich reaction in the synthesis of bispidine

Peter C. Ruenitz, Edward E. Smissman

Journal:

Journal of Heterocyclic Chemistry

Year:

1976

File:

PDF, 154 KB

1976

30

Synthesis and estrogen receptor selectivity of 1,1-bis(4-hydroxyphenyl)-2-(p-halophenyl)ethylenes

Ruenitz, Peter C., Bagley, Jerome R., Nanavati, Nitin T.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 751 KB

english, 1988

31

Structural characterization and biological effects of photocyclized products of tamoxifen irradiation

Susanne Wilson, Peter C. Ruenitz

Journal:

Journal of Pharmaceutical Sciences

Year:

1993

Language:

english

File:

PDF, 407 KB

english, 1993

32

Derivatization-liquid chromatographic assay of chloroacetaldehyde in biological samples

Jan A. Ruzicka, Peter C. Ruenitz

Journal:

Journal of Chromatography A

Year:

1990

Language:

english

File:

PDF, 291 KB

english, 1990

33

Analogs of sparteine. 3. Synthesis and conformational studies of some 2,3-substituted 7-methyl-3,7-diazabicyclo[3.3.1]nonanes

Ruenitz, Peter C., Smissman, Edward E.

Journal:

Journal of Organic Chemistry

Year:

1977

Language:

english

File:

PDF, 668 KB

english, 1977

34

Conformational studies of some 2-exo-alkyl-3-benzyl-3-azabicyclo[3.3.1]nonanes

Ruenitz, Peter C.

Journal:

Journal of Organic Chemistry

Year:

1978

Language:

english

File:

PDF, 548 KB

english, 1978

35

The preparation of carbon-14 labelled 1-[4-(2-diethylamino-ethoxy) phenyl]-1, 2-diphenyl-2-chloroethene (clomiphene) and 1-[4-(2-(N-pyrrolidinyl) ethoxy) phenyl]-2-(4-methoxyphenyl)-2-nitro-2-phenylethene (CI-628, nitromiphene)

Peter C. Ruenitz, Jerome R. Bagley

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1983

Language:

english

File:

PDF, 273 KB

english, 1983

36

Characterization of selective estrogen receptor modulator (SERM) activity in two triarylethylene oxybutyric acids

Valeria N. Rubin, Peter C. Ruenitz, Jason L. Boyd, F. Douglas Boudinot, Thomas E. Wiese

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 230 KB

english, 2002

37

Substituted-vinyl hydroxytriarylethylenes, 1-[4-[2-(diethylamino)ethoxy]phenyl]-1-(4-hydroxyphenyl)-2-phenylethylenes: synthesis and effects on MCF 7 breast cancer cell proliferation

Ruenitz, Peter C., Bagley, Jerome R., Watts, Colin K. W., Hall, Rosemary E., Sutherland, Robert L.

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 1.25 MB

english, 1986

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